The “dispensing well plate” (DWPTM) method is a technique to deliver fluidic jets or droplets with volumes of several nanoliters contact free to targets likemicro well plates or slides. A cheap and simple pneumatic actuation mechanism allows for the simultaneous delivery of a large number of different liquids. In this paper the dispensing dynamics of a DWP-type nanodispenser is studied theoretically. The device is modelled using computational fluid dynamics (CFD) simulations which are benchmarked to experimental data. Furthermore an analytical discussion is presented providing some insight into the dispensing dynamics. Based on these modelling approaches the dispensing process is studied in detail. Influence of system parameters like driving pressure, nozzle size, channel layout etc. on the jet formation and dispensed volume are quantified and design rules are given to improve the performance.