The modeling and simulation have gained numerous interests and been widely used in the design and optimization of complex microfluidic devices. In this study, an electrical equivalent network and a commercial CFD software package (CFD-ACE+ from CFDRC) are used to model and simulate the microfluidic microreactor array device. Geometrical variables have been studied including the microreactor depth and microchannel depth. The flow uniformity is tremendously improved by decreasing the microreactor depth, increasing the microchannel depth and/or changing the microchannel structure. In conclusion, by the proper design of this microfluidic system, the uniform flow and reaction in all microreactor cells can be achieved.