Research is being conducted at the University of Tennessee at Chattanooga (UTC) on the development and optimization of very small (microscale) bioreactors. These reactors use enzymes to promote beneficial chemical reactions, and the research effort includes both experimental and computational work. Since a principal focus of the engineering program at UTC is undergraduate instruction, there is a strong desire to include undergraduate students in this research in a meaningful way. In addition, potential employers would like for new engineering graduates to have experience in using commercial simulation software to model the behavior of complex physical phenomena. This paper describes UTC’s approach for integrating bioengineering-related simulation into the undergraduate classroom.