This is a 3D model of chemical binding kinetics in a millimeter-scale biosensor. The objective of the model is to investigate the effects of various kinetic parameters on the simulated response. A general objective of modeling such problems (not covered here) could be to evaluate the effectiveness of the mathematical model for extracting kinetic parameters from the sensogram.

CFD-VisCART is an automated 3D viscous unstructured adaptive Cartesian grid generation tool for handling complex geometries. This tutorial describes the steps for generating a Cartesian grid with different mesh resolutions on various geometries using CFD-VisCart.

The steady state conductive heat transfer to the air-gap between infinitely long concentric thick-walled cylinders is modeled and compared with an analytical solution. This is a step-by-step guided introductory tutorial for setting up a heat transfer model in CFD-ACE+.

In this tutorial, the geometry of a bent pipe is optimized. The bent section of the pipe must provide 90-degree change of direction for a fluid flowing through it. The objective is to determine the bend radius “R” that provides the minimal (optimal) pressure drop through the pipe.

Dielectrophoresis occurs because of the interaction between the induced dipole and the electric field. The interaction creates a net force, which depends on both the gradient of the electric field and electrical properties (permittivity and conductivity) of the particle and the media. The net force applies on partices, charged or not, and drives them to move. This technique can be used in the analysis, manipulation, and separation of cellular scale and nanometer scale particles like cells, DNA etc.

Electrokinetic injection is an alternate method of loading DNA sample onto the capillary separation matrix for capillary electrophoresis compared to hydrodynamic or manual loading.This transfer is directly dependent on the magnitude and duration of voltage applied across the capillaries. This tutorial investigates the electrokinetic injection and separation of analytes in a cross channel under the influence of an electric field.

This simulation models a two-dimensional cross channel geometry connecting four sample reservoirs. The process considered is electroosmotic driven flow from reservoir 1 to reservoir 2. The model examines the coupled fluid flow and electrostatic field at steady state. Electroosmotic flows are being considered for possible use in a number of biomedical applications involving flow in flow channels such as needless blood sampling for glucose testing.

The objective of this tutorial is to find the optimum bend radius R such that the pressure drop in the pipe is minimum for given a two-dimensional pipe with fixed velocity inlet.

This tutorial demonstrates the generation of a 3D geometry model and its discretization into a 3D structured grid. A Tesla-type valve geometry is used for this demonstration.

Proteins can be separated based on the relative density of positive or negatively charged residues. In iso-electro focusing with ions, a pH gradient is established in a gel using small multi-charged polymers such as polyampholytes. As the protein migrates into an acidic region of the gel, it will gain positive charge via protonation of the carboxylic and amino groups and vice versa. Eventually, the protein reaches a position in the pH gradient where its net charge is zero (defined as its pI or isoelectric point). At that point, the electrophoretic mobility is zero. Migration will cease, and concentration equilibrium of the focused protein is established.